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M94A3008.TXT
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1994-10-25
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Document 3008
DOCN M94A3008
TI Response to sublingual alfa interferon in Kaposi's sarcoma.
DT 9412
AU Lanjewar DN; Shetty CR; Shroff HJ; Hira SK; Grant Medical College,
Bombay, India.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):174 (abstract no. PB0124). Unique
Identifier : AIDSLINE ICA10/94369567
AB OBJECTIVE: To determine 1) therapeutic response of sublingual alfa
interferon, 2) the cause of death in case of AIDS-associated Kaposis
sarcoma. METHODS: An autopsy study was carried out on a 35 year old
female who presented with large papulonodular lesions on extremities for
which she was treated with sublingual alfa interferon. RESULTS: Autopsy
revealed disappearance of lesions of Kaposi's sarcoma over extremities.
Microscopic lesions of KS were noted in tongue, epiglottis, lung,
stomach, intestine and pancreas. Disseminated mycobacterial infection
was noted in lungs, lymph nodes, liver, spleen, kidney, adrenals and
uterus. DISCUSSION AND CONCLUSIONS: The lesions of Kaposi's sarcoma on
skin regressed with sublingual alfa interferon. However microscopic
lesions of KS were noted. The cause of death was due to disseminated
mycobacteriosis. Larger clinical trials with sublingual alfa interferon
in addition to management of associated opportunistic infections is
recommended.
DE Acquired Immunodeficiency Syndrome/MORTALITY/PATHOLOGY/*THERAPY
Administration, Sublingual Adult AIDS-Related Opportunistic
Infections/MORTALITY/PATHOLOGY Cause of Death Female Human
Interferon Alfa, Recombinant/*ADMINISTRATION & DOSAGE Neoplasms, Second
Primary/MORTALITY/PATHOLOGY/THERAPY Sarcoma,
Kaposi's/MORTALITY/PATHOLOGY/*THERAPY Skin/PATHOLOGY Skin
Neoplasms/MORTALITY/PATHOLOGY/*THERAPY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).